Port Saint Lucie is located in Tallahassee city, United States at the 27.2939, -80.3503 coordinates. Distance from Port Saint Lucie to other cities. are listed below, click on the city name to find distance between. Distance from Port Saint Lucie to Jacksonville 361 km, to Miami 170 km, to Tampa 220 km. The green marker indicates the location of Port Saint Lucie.