Karlsruhe is located in Stuttgart city, Germany at the 49.0094, 8.4044 coordinates. Distance from Karlsruhe to other cities. are listed below, click on the city name to find distance between. Distance from Karlsruhe to Mannheim 54 km, to Freiburg 120 km, to Heidelberg 49 km. The green marker indicates the location of Karlsruhe.